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Can I mix speeds of DDR? Will PC2100 work with PC1600?

Yes and no. For example, If you have a system with both PC1600 and PC2100 modules in it, the system will work, but it will only run at a speed of PC1600. A system will run at PC2100 if all the modules in it are PC2100, this assumes the system supports PC2100. This is similar to mixing PC133 and P100 SDR SDRAM modules in a system.